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Brendan Technologies, Inc.
1947 Camino Vida Roble
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Carlsbad, California 92008


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Published Papers

Manuscripts from Brendan Scientists

Measuring Parallelism, Linearity and Relative Potency in Bioassay and Immunoassay Data, Gottschalk PG, Dunn JR, Journal of Biopharmaceutical Statistics, 2005; 3:437-463.  (Free Reprint Available)

The Five Parameter Logistic:  A Characterization and Comparison with the Four-Parameter Logistic, Gottschalk PG, Dunn JR, Analytical Biochemistry, 2005; 343:54-65.    (Free Reprint Available)

Determining the Error of Dose Estimates and Minimum and Maximum Acceptable Concentrations from Assay with Nonlinear Dose-Response Curves, Gottschalk PG, Dunn JR, Computer Methods and Programs in Biomedicine, 2005; 80:204-215.    (Free Reprint Available)


Additional References


The following manuscripts include many of the initial techniques used for the methodologies and approaches in StatLIA.

Bates, D.M.; Watts, D.G.  Comparing Models. Nonlinear Regression Analysis and Its Applications; Wiley: New York 1988; 103-108.

Davidian, M., Carroll, R. J., and Smith, W.  Variance Functions and the Minimum Detectable Concentration in Assays, Biometrika 1988; 75/3, 549-556.

De Lean, A.P.; Munson, P.J.; and Rodbard D.  Simultaneous Analysis of Families of Sigmoidal Curves:  Application to Bioassay, Radioligand Assay, and Physiological Dose-Response Curves.  American Journal of Physiology 1978, 235 (E), 97-102.

Dudley, R.A.; Edwards, P; Ekins, R.P.; Finney, D.J.; McKenzie, I.G.M.; Raab, G.M.; Rodbard, D; Rodgers, R.P.C.  Guidelines for Immunoassay Data Processing. Clinical Chemistry 1985, 31 (8), 1264-1271.

Fernandez, A. A., Stevenson, G. W., Abraham, G. E., and Chiamori, N. Y.  Interrelations of the Various Mathematical Approaches to Radioimmunoassay.  Clinical Chemistry 1983; 29/2, 284-289.

Finney, D.J.; Schild, H.O.  Parallel Line Assay with Successive Adjustment of Doses.  British Journal of Pharmacology and Chemotherapy 1966, 28, 84-92.

Finney, D.J.; Phillips, P. The Form and Estimation of a Variance Function, with Particular Reference to Immunoassay.  Applied Statistics 1977, 26, 312-320.

Guardbasso, V.; Rodbard, D.; Munson, P.J. A Model-Free Approach to Estimation of Relative Potency in Dose-Response Curve Analysis.  American Journal of Physiology 1987, E (March), 357-64.
Raab, G.M.  Comparison of a Logistic and a Mass Action Curve for Radioimmunoassay Data.  Clinical Chemistry 1983, 29 (10), 1757-1761.

Raab, G.M.  Estimation of a Variance Function, with Application to Immunoassay.  Applied Statistics 1981, 3 (1), 32-40.

Rodbard, D.; Munson, P.J.; DeLean, A.  Improved Curve Fitting, Parallelism Testing, Characterization of Sensitivity and Specificity, Validation, and Optimization for Radioimmunoassays.  In Radioimmunoassay and Related Procedures in Medicine 1, Vienna, Italy 1977Int. Atomic Energy Agency 1978; 469-504.

Rodbard D.  Statistical Estimation of the Minimal Detectable Concentration (“Sensitivity”) for Radioligand Assays, Analytical Biochemistry 1978; 90, 1-12. (1978).

Straume M, Veldhuis JD, Johnson ML.  Model-independent Quantification of Measurement Error: Empirical Estimation of Discrete Variance Function Profiles Based on Standard Curves.  Methods in Enzymology 1994; 240:121-150.

Wild, David, Ed.  The Immunoassay Handbook.  Stockton: New York 1994.

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